Lap times might not differ much but there is a world of difference between a liter bike and 600 supersport when twisting the throttle, you can ring the 600's neck with relative impunity but crack the throttle too far on a liter bike and it will put you on your ass.
I agree that smaller stuff is safer but it's not a death sentence if they go the other way...most accidents on bikes aren't due to power per se, rather bad habits, target fixation, carrying too much speed into a corner etc.
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